Yes. This is what happened to me. I've been a very anxious person: cautious and worried about what other people thought of me. When I went to college, I didn't feel like I was succeeding as well as I did in high school. I began to worry that I wasn't able to succeed. I became so anxious every time I had an assignment that sometimes I wasn't able to start doing them at all. Of course I started doing even worse after that, and since up until then I'd been placing my self worth in how many things I could do well, my self-esteem spiraled, and I became severely depressed. I knew I needed help, so I called my campus mental health organization and made an appointment. It took 4 weeks to be seen, and the first appointment didn't help at all. But I kept going, and I worked with my therapist until I felt confident and happy again.