Too frustrated

I am frustrated more than ever. I feel like I wish I didn't exist. I feel completely alone. I feel unwanted. I feel like nobody wants me, nobody loves me. I sometimes just wish, I should run away and stay away from the world. Isolated. I am tired of putting efforts for everything and everyone. No one ever seems satisfied. I feel like I am not valued, at all. Has anyone ever felt like this? And if so, how do I not care about this? Because people matter. I just can't abandon them.